Marijuana

Marijuana is the most commonly used illicit drug in the United States. A dry, shredded green/brown mix of flowers, stems, seeds, and leaves of the hemp plant Cannabis sativa, it usually is smoked as a cigarette (joint, nail), or in a pipe (bong). It also is smoked in blunts, which are cigars that have been emptied of tobacco and refilled with marijuana, often in combination with another drug. Use also might include mixing marijuana in food or brewing it as a tea. As a more concentrated, resinous form it is called hashish and, as a sticky black liquid, hash oil. Marijuana smoke has a pungent and distinctive, usually sweet-and-sour odor. There are countless street terms for marijuana including pot, herb, weed, grass, widow, ganja, and hash, as well as terms derived from trademarked varieties of cannabis, such as Bubble Gum®, Northern Lights®, Juicy Fruit®, Afghani #1®, and a number of Skunk varieties.

The main active chemical in marijuana is THC (delta-9-tetrahydrocannabinol). The membranes of certain nerve cells in the brain contain protein receptors that bind to THC. Once securely in place, THC kicks off a series of cellular reactions that ultimately lead to the high that users experience when they smoke marijuana.

Extent of Use

In 2001, over 12 million Americans age 12 and older used marijuana at least once in the month prior to being surveyed. That is more than three quarters (76 percent) of the total number of Americans who used any illicit drug in the past month in 2001. Of the 76 percent, more than half (56 percent) consumed only marijuana; 20 percent used marijuana and another illicit drug; and the remaining 24 percent used an illicit drug or drugs other than marijuana(1).

Although marijuana is the most commonly used illicit drug in the United States, among students in the 8th, 10th, and 12th grades nationwide its use remained stable from 1999 through 2001(2). Among 8th graders, however, past year use has decreased, from 18.3 percent in 1996 to 15.4 percent in 2001. Also in 2001, more than half (57.4 percent) of 12th graders believed it was harmful to smoke marijuana regularly and 79.3 percent disapproved of regular marijuana use. Since 1975, 83 percent to 90 percent of every 12th grade class surveyed has found it "fairly easy" or "very easy" to obtain marijuana(3).

Data for drug-related hospital emergency department visits in the continental United States recently showed a 15 percent increase in the number of visits to an emergency room that were induced by or related to the use of marijuana (referred to as mentions), from 96,426 in 2000 to 110,512 in 2001. The 12 to 34 age range was involved most frequently in these mentions. For emergency room patients in the 12 to 17 age range, the rate of marijuana mentions increased 23 percent between 1999 and 2001 (from 55 to 68 per 100,000 population) and 126 percent (from 30 to 68 per 100,000 population) since 1994(4).

Effects on the Brain

Scientists have learned a great deal about how THC acts in the brain to produce its many effects. When someone smokes marijuana, THC rapidly passes from the lungs into the bloodstream, which carries the chemical to organs throughout the body, including the brain.

In the brain, THC connects to specific sites called cannabinoid receptors on nerve cells and influences the activity of those cells. Some brain areas have many cannabinoid receptors; others have few or none. Many cannabinoid receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement(5).

The short-term effects of marijuana use can include problems with memory and learning; distorted perception; difficulty in thinking and problem solving; loss of coordination; and increased heart rate. Research findings for long-term marijuana use indicate some changes in the brain similar to those seen after long-term use of other major drugs of abuse. For example, cannabinoid (THC or synthetic forms of THC) withdrawal in chronically exposed animals leads to an increase in the activation of the stress-response system(6) and changes in the activity of nerve cells containing dopamine(7). Dopamine neurons are involved in the regulation of motivation and reward, and are directly or indirectly affected by all drugs of abuse.

Effects on the Heart

One study has indicated that a user’s risk of heart attack more than quadruples in the first hour after smoking marijuana(8). The researchers suggest that such an effect might occur from marijuana’s effects on blood pressure and heart rate and reduced oxygen-carrying capacity of blood.

Effects on the Lungs

A study of 450 individuals found that people who smoke marijuana frequently but do not smoke tobacco have more health problems and miss more days of work than nonsmokers(9). Many of the extra sick days among the marijuana smokers in the study were for respiratory illnesses.

Even infrequent use can cause burning and stinging of the mouth and throat, often accompanied by a heavy cough. Someone who smokes marijuana regularly may have many of the same respiratory problems that tobacco smokers do, such as daily cough and phlegm production, more frequent acute chest illness, a heightened risk of lung infections, and a greater tendency to obstructed airways(10).

Cancer of the respiratory tract and lungs may also be promoted by marijuana smoke(11). A study comparing 173 cancer patients and 176 healthy individuals produced strong evidence that smoking marijuana increases the likelihood of developing cancer of the head or neck, and the more marijuana smoked the greater the increase(12). A statistical analysis of the data suggested that marijuana smoking doubled or tripled the risk of these cancers.

Marijuana use has the potential to promote cancer of the lungs and other parts of the respiratory tract because it contains irritants and carcinogens(13). In fact, marijuana smoke contains 50 to 70 percent more carcinogenic hydrocarbons than does tobacco smoke(14). It also produces high levels of an enzyme that converts certain hydrocarbons into their carcinogenic form—levels that may accelerate the changes that ultimately produce malignant cells(15). Marijuana users usually inhale more deeply and hold their breath longer than tobacco smokers do, which increases the lungs’ exposure to carcinogenic smoke. These facts suggest that, puff for puff, smoking marijuana may increase the risk of cancer more than smoking tobacco.

Other Health Effects

Some of marijuana's adverse health effects may occur because THC impairs the immune system’s ability to fight off infectious diseases and cancer. In laboratory experiments that exposed animal and human cells to THC or other marijuana ingredients, the normal disease-preventing reactions of many of the key types of immune cells were inhibited(16). In other studies, mice exposed to THC or related substances were more likely than unexposed mice to develop bacterial infections and tumors(17,18).

Effects of Heavy Marijuana Use on Learning and Social Behavior

Depression(19), anxiety(20), and personality disturbances(21) are all associated with marijuana use. Research clearly demonstrates that marijuana use has potential to cause problems in daily life or make a person’s existing problems worse. Because marijuana compromises the ability to learn and remember information, the more a person uses marijuana the more he or she is likely to fall behind in accumulating intellectual, job, or social skills. Moreover, research has shown that marijuana’s adverse impact on memory and learning can last for days or weeks after the acute effects of the drug wear off(22,23).

Students who smoke marijuana get lower grades and are less likely to graduate from high school, compared to their non-smoking peers(24,25,26,27). In one study, researchers compared marijuana-smoking and non-smoking 12th-graders’ scores on standardized tests of verbal and mathematical skills. Although all of the students had scored equally well in 4th grade, the marijuana smokers’ scores were significantly lower in 12th grade(28).

A study of 129 college students found that, for heavy users of marijuana (those who smoked the drug at least 27 of the preceding 30 days), critical skills related to attention, memory, and learning were significantly impaired even after they had not used the drug for at least 24 hours(29). The heavy marijuana users in the study had more trouble sustaining and shifting their attention and in registering, organizing, and using information than did the study participants who had used marijuana no more than 3 of the previous 30 days. As a result, someone who smokes marijuana once daily may be functioning at a reduced intellectual level all of the time.

More recently, the same researchers showed that the ability of a group of long-term heavy marijuana users to recall words from a list remained impaired for a week after quitting, but returned to normal within 4 weeks(30). An implication of this finding is that some cognitive abilities may be restored in individuals who quit smoking marijuana, even after long-term heavy use.

Workers who smoke marijuana are more likely than their coworkers to have problems on the job. Several studies associate workers' marijuana smoking with increased absences, tardiness, accidents, workers' compensation claims, and job turnover. A study of municipal workers found that those who used marijuana on or off the job reported more "withdrawal behaviors"—such as leaving work without permission, daydreaming, spending work time on personal matters, and shirking tasks—that adversely affect productivity and morale(31).

Effects on Pregnancy

Research has shown that babies born to women who used marijuana during their pregnancies display altered responses to visual stimuli, increased tremulousness, and a high-pitched cry, which may indicate problems with neurological development(32). During infancy and preschool years, marijuana-exposed children have been observed to have more behavioral problems and poorer performance on tasks of visual perception, language comprehension, sustained attention, and memory(33,34). In school, these children are more likely to exhibit deficits in decision-making skills, memory, and the ability to remain attentive(35,36,37).

Addictive Potential

Long-term marijuana use can lead to addiction for some people; that is, they use the drug compulsively even though it often interferes with family, school, work, and recreational activities. Drug craving and withdrawal symptoms can make it hard for long-term marijuana smokers to stop using the drug. People trying to quit report irritability, sleeplessness, and anxiety(38). They also display increased aggression on psychological tests, peaking approximately one week after the last use of the drug(39).

Genetic Vulnerability

Scientists have found that whether an individual has positive or negative sensations after smoking marijuana can be influenced by heredity. A 1997 study(40) demonstrated that identical male twins were more likely than non-identical male twins to report similar responses to marijuana use, indicating a genetic basis for their response to the drug. (Identical twins share all of their genes.)

It also was discovered that the twins' shared or family environment before age 18 had no detectable influence on their response to marijuana. Certain environmental factors, however, such as the availability of marijuana, expectations about how the drug would affect them, the influence of friends and social contacts, and other factors that differentiate experiences of identical twins were found to have an important effect.

Treating Marijuana Problems

The latest treatment data indicate that, in 1999, marijuana was the primary drug of abuse in about 14 percent (223,597) of all admissions to treatment facilities in the United States. Marijuana admissions were primarily male (77 percent), white (58 percent), and young (47 percent under 20 years old). Those in treatment for primary marijuana use had begun use at an early age; 57 percent had used it by age 14 and 92 percent had used it by 18(41).

One study of adult marijuana users found comparable benefits from a 14-session cognitive-behavioral group treatment and a 2-session individual treatment that included motivational interviewing and advice on ways to reduce marijuana use. Participants were mostly men in their early thirties who had smoked marijuana daily for more than 10 years. By increasing patients' awareness of what triggers their marijuana use, both treatments sought to help patients devise avoidance strategies. Use, dependence symptoms, and psychosocial problems decreased for at least 1 year following both treatments; about 30 percent of users were abstinent during the last 3-month followup period(42).

Another study suggests that giving patients vouchers that they can redeem for goods—such as movie passes, sporting equipment, or vocational training—may further improve outcomes(43).

Although no medications are currently available for treating marijuana abuse, recent discoveries about the workings of the THC receptors have raised the possibility of eventually developing a medication that will block the intoxicating effects of THC. Such a medication might be used to prevent relapse to marijuana abuse by lessening or eliminating its appeal.

Percentage of 8th-Graders Who Have Used Marijuana:
Monitoring the Future Study, 2001

	1992	1993	1994	1995	1996	1997	1998	1999	2000	2001
Ever Used	11.2	12.6	16.7	19.9	23.1	22.6	22.2	22.0	20.3	20.4
Used in Past Year	7.2	9.2	13.0	15.8	18.3	17.7	16.9	16.5	15.6	15.4
Used in Past Month	3.7	5.1	7.8	9.1	11.3	10.2	9.7	9.7	9.1	9.2
Daily Use in Past Month	0.2	0.4	0.7	0.8	1.5	1.1	1.1	1.4	1.3	1.3

 

Percentage of 10th-Graders Who Have Used Marijuana:
Monitoring the Future Study, 2001

Percentage of 12th-Graders Who Have Used Marijuana
Monitoring the Future Study, 2001

These data are from the 2001 Monitoring the Future (MTF) Survey, funded by National Institute on Drug Abuse, National Institutes of Health, DHHS, and conducted by the University of Michigan’s Institute for Social Research. The survey has tracked 12th graders’ illicit drug use and related attitudes since 1975; in 1991, 8th and 10th graders were added to the study. The latest data (2001) are online at www.drugabuse.gov.

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1 These data are from the annual National Household Survey on Drug Abuse, funded by the Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services (DHHS). The latest data (2001) are available at 1-800-729-6686 or online at www.samhsa.gov.

2 These data are from the Monitoring the Future Survey, funded by National Institute on Drug Abuse, National Institutes of Health, DHHS, and conducted by the University of Michigan’s Institute for Social Research. The survey has tracked 12th graders’ illicit drug use and related attitudes since 1975; in 1991, 8th and 10th graders were added to the study. The latest data (2001) are online at www.drugabuse.gov.

3 Ibid.

4 These data are from the annual Drug Abuse Warning Network, funded by the Substance Abuse and Mental Health Services Administration, DHHS. The survey provides information about emergency department visits that are induced by or related to the use of an illicit drug or the nonmedical use of a legal drug. The latest data (2001) are available at 1-800-729-6686 or online at www.samhsa.gov

5 Herkenham M, Lynn A., Little MD, Johnson MR, et al: Cannabinoid receptor localization in the brain. Proc Natl Acad Sci, USA 87:1932-1936, 1990.

6 Rodriguez de Fonseca F, et al: Activation of cortocotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 276(5321):2050-2064, 1997.

7 Diana M, Melis M, Muntoni AL, et al: Mesolimbic dopaminergic decline after cannabinoid withdrawal. Proc. Natl. Acad. Sci 95:10269-10273, 1998.

8 Mittleman MA, Lewis RA, Maclure M, et al: Triggering myocardial infarction by marijuana. Circulation 103:2805-2809, 2001.

9 Polen M R, Sidney S, Tekawa IS, et al: Health care use by frequent marijuana smokers who do not smoke tobacco. West J Med 158:596-601, 1993.

10 Tashkin DP: Pulmonary complications of smoked substance abuse. West J Med 152:525-530, 1990.

11 Ibid.

12 Zhang ZF, Morgenstern H, Spitz MR, et al: Marijuana use and increased risk of squamous cell carcinoma of the head and neck. Cancer Epidemiology, Biomarkers & Prevention 6:1071-1078, 1999.

13 Sridhar KS, Raub WA, Weatherby, NL Jr, et al: Possible role of marijuana smoking as a carcinogen in the development of lung cancer at a young age. Journal of Psychoactive Drugs 26(3):285-288, 1994.

14 Hoffman D, Brunnemann KD, Gori GB, et al: On the carcinogenicity of marijuana smoke. In: VC Runeckles, ed, Recent Advances in Phytochemistry. New York. Plenum, 1975.

15 Cohen S: Adverse effects of marijuana: selected issues. Annals of the New York Academy of Sciences 362:119-124, 1981.

16 Adams IB, Martin BR: Cannabis: pharmacology and toxicology in animals and humans. Addiction 91:1585-1614, 1996.

17 Klein TW, Newton C, Friedman H: Resistance to Legionella pneumophila suppressed by the marijuana component, tetrahydrocannabinol. J Infectious Disease 169:1177-1179, 1994.

18 Zhu L, Stolina M, Sharma S, et al: Delta-9 tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunology, 2000, pp. 373-380.

19 Brook JS, et al: The effect of early marijuana use on later anxiety and depressive symptoms. NYS Psychologist, January 2001, pp. 35-39.

20 Green BE, Ritter C: Marijuana use and depression.
J Health Soc Behav 41(1):40-49, 2000.

21 Brook JS, Cohen P, Brook DW: Longitudinal study of co-occurring psychiatric disorders and substance use. J Acad Child and Adolescent Psych 37:322-330, 1998.

22 Pope HG, Yurgelun-Todd D: The residual cognitive effects of heavy marijuana use in college students. JAMA 272(7):521-527, 1996.

23 Block RI, Ghoneim MM: Effects of chronic marijuana use on human cognition. Psychopharmacology 100(1-2):219-228, 1993.

24 Lynskey M, Hall W: The effects of adolescent cannabis use on educational attainment: a review. Addiction 95(11):1621-1630, 2000.

25 Kandel DB, Davies M: High school students who use crack and other drugs. Arch Gen Psychiatry 53(1):71-80, 1996.

26 Rob M, Reynolds I, Finlayson PF: Adolescent marijuana use: risk factors and implications. Aust NZ J Psychiatry 24(1):45-56, 1990.

27 Brook JS, Balka EB, Whiteman M: The risks for late adolescence of early adolescent marijuana use. Am J Public Health 89(10):1549-1554, 1999.

28 Block RI, Ghoneim MM: Effects of chronic marijuana use on human cognition. Psychopharmacology 100(1-2):219 228, 1993.

29 Ibid ref 22.

30 Pope, Gruber, Hudson, et al: Neuropsychological performance in long-term cannabis users. Archives of General Psychiatry.

31 Lehman WE, Simpson DD: Employee substance abuse and on-the-job behaviors. Journal of Applied Psychology 77(3):309-321, 1992.

32 Lester, BM; Dreher, M: Effects of marijuana use during pregnancy on newborn cry. Child Development 60:764-771, 1989.

33 Fried, PA: The Ottawa prenatal prospective study (OPPS): methodological issues and findings—it’s easy to throw the baby out with the bath water. Life Sciences 56:2159-2168, 1995.

34 Fried, PA: Prenatal exposure to marihuana and tobacco during infancy, early and middle childhood: effects and an attempt at synthesis. Arch Toxicol Supp 17:233-60, 1995.

35 Ibid ref 33.

36 Ibid ref 34.

37 Cornelius MD, Taylor PM, Geva D, et al: Prenatal tobacco and marijuana use among adolescents: effects on offspring gestational age, growth, and morphology. Pediatrics 95:738-743, 1995.

38 Kouri EM, Pope HG, Lukas SE: Changes in aggressive behavior during withdrawal from long-term marijuana use. Psychopharmacology 143:302-308, 1999.

39 Haney M, Ward AS, Comer SD, et al: Abstinence symptoms following smoked marijuana in humans. Psychopharmacology 141:395-404, 1999.

40 Lyons MJ, et al: Addiction 92(4):409-417, 1997.

41 These data from the Treatment Episode Data Set (TEDS) 1994-1999: National Admissions to Substance Abuse Treatment Services, November 2001, funded by the Substance Abuse and Mental Health Service Administration, DHHS. The latest data are available at 1-800-729-6686 or online at www.samhsa.gov.

42 Stephens RS, Roffman RA, Curtin L: Comparison of extended versus brief treatments for marijuana use. J Consult Clin Psychol 68(5):898-908, 2000.

43 Budney AJ, Higgins ST, Radonovich KJ, et al: Adding voucher-based incentives to coping skills and motivational enhancement improves outcomes during treatment for marijuana dependence. J Consult Clin Psychol 68(6):1051-1061, 2000.

Source: National Institute on Drug Abuse